Simonović lab

Our aim is to visualize, and thus explain at the structural level, processes that govern fidelity of gene translation. Models systems under the study include,  but are not limited to, enzymes and complexes that facilitate and regulate protein synthesis, tRNA-dependent synthesis of amino acids, genetic code reassignment events, and genome editing. Also, we study how faults in components of the translational machinery cause various illnesses. The goal is to  expand our understanding and knowledge about fundamental biological processes in living organisms.